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    The Guardian of the Genome.

    In the complex architecture of human biology, Sirt 6 is the "Master Switch." It is the primary regulator standing between healthy function and cellular decay.

A Target, Not Just a Theory.

For years, research focused on SIRT1. However, emerging data has shifted the spotlight to SIRT6, a powerful NAD+-dependent enzyme that regulates health span and longevity. The difference is profound. While SIRT1 is involved in metabolic regulation, SIRT6 has been identified as a singular force that determines the rate of ageing. It is not just about living longer; it is about maintaining the biological function of youth.

The Silent Decline.

Evolution did not design you to live forever. Research indicates that SIRT6 expression naturally plummets as we age. By age 50, your cells may possess significantly less repair capacity than they did at age 20.

This decline leaves your genome vulnerable to the accumulation of errors that drive frailty. We don't just supplement your diet; we aim to reactivate the repair signal that time has switched off.

  • Age 20: Peak Efficiency (Optimal Repair).
  • Age 50: Critical Decline (Accumulation of Errors).
  • The Solution: Restore the signal.

Mechanisms of Action - Dark Mode

The 4 Mechanisms of Action

I.

Genomic Stability

"Guardian of the Genome" — Maintaining DNA integrity.

  • DNA Repair: Master regulator enhancing pathways to fix double-strand breaks.
  • Telomere Maintenance: Protects chromosome caps preventing instability.
  • Silencing "Junk DNA": Suppresses LINE1 elements to keep the genome stable.
II.

The Human Connection

The Centenarian Allele found in 450 Ashkenazi Jewish centenarians.

There is a direct link to human longevity. A specific SIRT6 variant creates an enzyme with enhanced mono-ADP-ribosylase (mADPr) activity.

This super-charged version efficiently silences "junk DNA" and repairs breaks, providing proof that SIRT6 contributes directly to living to 100.

III.

Metabolic Homeostasis

The Energy Reset — Restoring "young-like" energy systems.

  • Glucose Control: Suppresses gluconeogenesis to maintain healthy blood sugar.
  • Fat Regulation: Protects against metabolic damage from high-fat diets.
  • NAD+ Preservation: Preserves the critical fuel molecule for cellular energy.
IV.

Inflammation & Frailty

The Anti-Senescence Shield — Reversing physical decline.

  • Reducing Frailty: Activated SIRT6 results in increased voluntary physical activity.
  • Controlling "Zombie" Secretions: Regulates SASP to reduce toxic inflammatory signals from senescent cells.

The Intersection of Ageing

SIRT6 is unique because it sits at the nexus of the critical hallmarks of ageing: genomic instability, metabolic dysfunction, and chronic inflammation. By protecting the genetic blueprint and restoring youthful metabolic function, SIRT6 represents one of the most validated targets for interventions designed to extend human health span.